TGF‐β plays an inhibitory role in the early stage of the disease, but in the late stage of the disease, under pathological conditions, overexpression of TGF‐β will promote epithelial interstitial transformation (EMT),41 extracellular matrix deposition (ECM),42 and the formation of cancer‐associated fibroblasts (CAFs),43 leading to the formation of fibrotic diseases and cancer.44 The gene discussed is TGFB1; the disease is cancer.