Studies have shown that many TGF‐β signal‐related genes derived from CAFs are involved in the activation of CAFs and play an important role in the signal crosstalk between fibroblasts and ovarian cancer cells, such as COL11A1, CRMAP2, versican, POSTN, etc.10, 17, 18, 19These proteins are involved in the continuous shuffling of the extracellular matrix, triggering a cascade of reactions and building new physical barriers that support the tumor's pathogenic processes. This evidence concerns the gene TGFB1 and ovarian cancer.