Activated CAFs specifically express α‐smooth muscle actin (α‐SMA), fibroblast activating protein (FAP), fibroblast specific protein 1 (FSP‐1), and other markers,14, 15 which promote cancer cell survival, proliferation, and invasion through increased growth factors and extracellular matrix (ECM), and enhanced metabolic activity.16 This evidence concerns the gene S100A4 and cancer.