Our manuscript studied that SLC7A1 enriched in cancer‐associated fibroblasts (CAFs) was upregulated by TGF‐β1; CAFs overexpressing SLC7A1 supported the migration and invasion of tumor cells in high‐grade serous ovarian cancer (HGSOC); SLC7A1 is highly expressed in ovarian cancer and is involved in ERK phosphorylation and EMT signaling in MAPK signaling pathway. Here, SLC7A1 is linked to ovarian serous adenocarcinoma.