NPPB and heart failure: Unfortunately, when focusing on how each of the molecular layers could be contributing to or being the consequence of biochemically measured infarct size, no such relationship was found except for plasma NT-proBNP levels (Table S9)—a known marker for heart failure.15 This lack of association might have resulted from assessing each molecular parameter separately or not considering all potentially relevant clinical and donor variables in the model.40 Such a model that considers all these parameters requires a larger sample size.