Amyloid β-protein (Aβ), neurogenic fibrillary tangles (NFTs), and hyperphosphorylated tau proteins aggregate abnormally to form plaques and impair neurological functioning; this is the pathological underpinning of AD (Zhou et al., 2015; He et al., 2023; Zhang X. W. et al., 2023). Here, MAPT is linked to Alzheimer disease.