BMI: body mass index; NASH: nonalcoholic steatohepatitis; Hep B: hepatitis B; Hep C: hepatitis C; HCC: hepatocellular carcinoma; AKI: acute kidney injury; HRS: hepatorenal syndrome; ATN: acute tubular necrosis; BP: blood pressure; ALT: alanine transaminase; AST: aspartate transaminase; Alk Phos: alkaline phosphatase; BUN: blood urea nitrogen; MELD: Model for End-Stage Liver Disease; LOS: length of stay; SBP: spontaneous bacterial peritonitis. The gene discussed is ALK; the disease is Renal insufficiency.