Post-TAVR patients were prescribed a single antithrombotic medication, including antiplatelets (such as aspirin or P2Y12 inhibitors) and/or anticoagulants in patients with atrial fibrillation (such as novel oral anticoagulants like factor X inhibitors), which is reported to be crucial for the prevention of ischemic strokes post-TAVR [16]. Here, P2RY12 is linked to ischemic stroke.