34,35 Cancer-associated fibroblast (CAF) is a major cellular component of the tumor stroma; several therapeutics are being investigated to target fibroblast activation protein or their paracrine signaling pathways that is platelet-derived growth factor receptor, epithelial-mesenchymal transition (EMT), receptor tyrosine kinase and transforming growth factor (TGF) signaling pathways. This evidence concerns the gene NTRK1 and neoplasm.