64 The architecture and cellular components of the tumor microenvironment help create resistance to immune cells. In addition, there is the recruitment of immunosuppressive cells and the expression of immune checkpoint inhibitors such as Programmed Death Ligand-1 (PD-L1). 65 The tumor mainly affects metabolism, vascularisation, and the immune system in the tumor microenvironment. Moreover, it modifies tissue-resident immune cells into a tumor-promoting profile; thus, immune cells promote tumor growth and proliferation. 66. The gene discussed is CD274; the disease is neoplasm.