In this study, identical mutation sites in CHCHD2 (T61I) (16), LRRK2 (G2019S, R1441G) (3, 30, 31), SNCA (E46K, A53T, duplication) (8, 40, 41), and GBA (N370S, E326K, L444P, N409S/D409H) (4, 5, 10, 52–56) were identified in both skin biopsies and brain autopsies, with synucleinopathy detected in both cutaneous and cerebral samples. This evidence concerns the gene CHCHD2 and synucleinopathy.