In conclusion, our study of peripheral cutaneous synucleinopathy characteristics in patients with genetic PD yielded several key findings: (i) P-α-syn was deposited in the peripheral cutaneous nerves of PD patients with CHCHD2, LRRK2, or GBA mutations but not in those with RAB39B or PRKN mutations. This evidence concerns the gene PRKN and synucleinopathy.