The pathways of natural products targeting angiogenesis in gynecological cancer were classified through comparative analyses (Figure 4): (1) VEGF-targeted approaches, focusing on this pivotal regulator of angiogenesis; (2) PI3K/AKT-targeted strategies, which play a crucial role in tumor angiogenesis regulation; (3) HIF-1α-mediated regulation of tumor angiogenesis; (4) ERK-targeted interventions for regulating tumor angiogenesis; (5) Others. The gene discussed is AKT1; the disease is female reproductive organ cancer.