We confirmed the co-alteration between ERG/PTEN and further captured SHQ1, HDAC5, and TP53 loss alterations as significantly co-altered with ERG and PTEN. These findings suggest SHQ1, HDAC5, and TP53 loss alterations may also be molecular features that help promote progression in primary PCa. Here, TP53 is linked to posterior cortical atrophy.