In the gene expression (logFC: 0.91, P-Value: 9.04E-03) and PPI network (highest betweenness score: 0.23, Degree: 37, and Closeness score: 0.60) results, TNF was discovered as an essential hub gene involved in NAFLD that could be affected by Calebin-A. This evidence concerns the gene TNF and metabolic dysfunction-associated steatotic liver disease.