GLA and Fabry disease: This hypothesis is supported by a human study that found increased cytokine gene expression in peripheral blood mononuclear cells (PBMC) of Fabry disease patients, correlating with the Fabry pain phenotype.34 Such pro-inflammatory effects of Gb3 have also been observed.19 In addition, in the Gla KO mouse model, Gb3 may interact with pattern recognition receptors (PRR) on immune cells.