These samples are from two patients that present the clinical features of Coffin-Siris syndrome 4 (CSS4)26 and have likely pathogenic variants in the chromatin remodeler SMARCA4, a known CSS4-related gene: c.3068A>G p.(E1023G) in GM190941 and c.1646G>T p.(R549L) in GM223379. This evidence concerns the gene SMARCA4 and intellectual disability, autosomal dominant 16.