For example, there is a specific signature called CSS_c.6200 that is associated with variants in the terminal region of ARID1B or ARID1A. 10Additionally, there are domain-specific DNAm episignatures in ADNP,14 a distinct DNAm signature in SRCAP associated with Floating-Harbor syndrome (FLHS) compared with non-FLHS SRCAP-related NDD,47 and finally a unique CSS4_c.2656 variant-specific episignature.10 The gene discussed is ARID1B; the disease is Neurodevelopmental delay.