Likewise, research by Madelene et al.,28 utilizing 5‐aza‐2'deoxycytidine (5‐aza‐dC) to reactivate p16 in Tu159 HNSCC cells, resulting in inhibited tumour growth, supports the functional implications of CDKN2A expression we observed. Here, CDKN2A is linked to head and neck squamous cell carcinoma.