However, A marked reduction was obtained in RAW 264.7 (51.6% as compared to the infected control, p = 0.000333, F (3, 20) = 9.87) (Fig. 7E), and BMDM (Fig. S5C) when inhibitors of both NFATc1 (INCA-6, 10 μM for 1 h) and HIF-1α (GN44028, 10 μM for 1 h) were used in combination, suggesting a synergistic effect of both NFATc1 and HIF-1α in infection mediated IL-33 induction. The gene discussed is NFATC1; the disease is infection.