In addition, genes related to immune diseases (e.g., BID, SMARCD3, ATP6V1E1, NFKB2), energy metabolism (e.g., HAO1, NDUFA7, CERS4, MTHFD1), and other factors were also screened (Fig. 4B, Table S7). The gene discussed is MTHFD1; the disease is immune system disorder.