PIK3CA and pachyonychia congenita: The main genetic alterations in PC affect androgen receptor (AR), Phosphatidylinositol-3-kinase/ Phosphatase and tensin homolog (PIK3CA–PTEN), WNT, and genes involved in DNA repair signaling pathways (BRCA1, BRCA2, ATM, CHEK2) [39].Treatment options for PC depend on the stage of the disease.