Eight of them had not been detected by routine testing (FANCA p.W911Dfs*31 in GE02 pancreatic cfDNA, 3 NRAS p.Q61K in GE17 and GE15 melanoma and in GE11 cholangiocarcinoma, a NRAS p.G13D in GE22 pancreatic cancer, an IDH2 p.R172S in GE11 cholangiocarcinoma, and an IDH2 p.R140Q in GE14 melanoma). The gene discussed is IDH2; the disease is melanoma.