Similar findings have been discovered in our study, a low expression in SuHx-induced rat model and CoCl2-induced H9c2 cell hypoxia model (Figs. 6A-C and S2).On the contrary, the expression of SIRT3 can reduce the apoptosis of cardiomyocytes in a cardiac hypertrophy model [27]. Here, SIRT3 is linked to cardiac hypertrophy.