In Fig. 2, the SMR analysis provided suggestive evidence that a one standard deviation (SD) increases in the blood expression of the KCNJ11 gene reduced the incidence of COPD by 13% (OR = 0.87, 95% CI = 0.79–0.95; P = 0.002). This evidence concerns the gene KCNJ11 and chronic obstructive pulmonary disease.