MAPT and tauopathy: In addition, we posit early exposure to r-mTBI (pre-onset of tau astrogliopathy) will exacerbate tau accumulation in astrocytes and brain-wide tauopathy, increase astroglial and microglial responses, cause more pronounced dysregulation of astroglial homeostatic markers and transcriptional changes in mice harboring tau-bearing astrocytes compared to WT and CaMKIIαP301L models.