In another meta-analysis that included nearly 30,000 people, in patients with atrial fibrillation, elevated BNP and NT-proBNP levels were significantly associated with adverse outcomes, including mortality (RR = 1.92) and stroke (RR = 1.92) = 2.53), indicating that the level of BNP/NT-proBNP plays an important role in the risk stratification of the prognosis of patients with atrial fibrillation [18]. This evidence concerns the gene NPPB and Stroke.