GO and KEGG analysis of upregulated genes were closely related to cervical cancer: RIG-I participated in interferon production to activate innate antiviral immunity, apoptotic program, and antitumor immunity [26–29]; transforming growth factor beta (TGF-β1) functioned as a tumor inhibitor in precancerous lesions and early-stage cancers of cervix whereas as a tumor promoter in later stage [30, 31]; the epithelial to mesenchymal transition (EMT) played an important role in cervical cancer progression and metastasis [32]. The gene discussed is RIGI; the disease is cervical cancer.