RNAseq revealed some key genes in cervical cancer: the methylation level of POU4F3 can be used as a marker of cervical cancer [39]; hypermethylation of IGF2 is associated with a high risk of cervical cancer [40]; lncRNA TTN-AS1 participated in the development of cervical cancer by regulating the miR-573-E2F3 axis [41]. The gene discussed is E2F3; the disease is cervical cancer.