The Gene Ontology (GO) analyses for these genes showed that genes upregulated by HPV16-miR-H1 were closely related to cervical cancer: positive regulation of RIG-I signaling pathway, cellular response to cytokine stimulus (including transforming growth factor beta and interferon-gamma), epithelial to mesenchymal transition, apoptotic process, innate immune response, response to the virus (Fig. 3E). This evidence concerns the gene IFNG and cervical cancer.