It had been reported that the insertion site of HPV16 in SiHa cells is 13q22, but the overlapping genes of CHIP-seq and RNA-seq are not on chromosome 13, so HPV16-miR-H1 and HPV16-miR-H6 may play the role of activating enhancers through the three-dimensional structure of the genome, which may be a general rule of the role of HPV16-miRNAs in cervical cancer [10, 38]. The gene discussed is STUB1; the disease is cervical carcinoma.