By comparison, RIPK3 was upregulated in intestinal epithelial cells (Fig. 3E,F), certain vascular beds (Fig. 3G,H), and in the liver (Fig. 3I,J); the main sites where RIPK1- and RIPK3-mediated signaling during SIRS has been implicated by knock-in and knockout mouse studies (Duprez et al, 2011; Newton et al, 2016; Zelic et al, 2018). This evidence concerns the gene RIPK3 and systemic inflammatory response syndrome.