Thus, the identification of EGF signaling-triggered PGAM1 Y119 phosphorylation not only interprets the molecular mechanism for PKM2 recognition, but also ideally specifies the occurrence of the phosphorylation of both Y119 and H11 in tumor cells, providing a promising target for cancer therapy that may leave the normal proliferating cells unaffected. Here, PGAM1 is linked to neoplasm.