Intriguingly, it is prevalent that EGF signaling is activated in many tumors such as lung cancers and breast cancers, and has shown to be important for aerobic glycolysis by regulating the glycolytic enzymes posttranslational modifications (Lv et al, 2013; Moscatello et al, 1995; Nicholson et al, 2001; Yang et al, 2012b). This evidence concerns the gene EGF and breast carcinoma.