LRRK2 and Parkinson disease: Consistent with conclusions drawn from the experiments with mLRRK2G2019S KI and hLRRK2WT Tg mice, this again decouples the severity of acute DSS response from the severity and onset of motor impairment, highlighting a role for DSS-induced intestinal inflammation as an environmental trigger that potentiates genetic risk for PD symptoms in LRRK2 carriers.