To evaluate roles for sex chromosomes in causing greater male risk for PD-related behavioral and neuropathological symptoms in response to prodromal intestinal inflammation35, we mated XX female hLRRK2G2019S Tg mice with XY-Sry gonadal male mice in which the testis determining gene Sry was removed from the Y chromosome and inserted autosomally35,36. The gene discussed is SRY; the disease is Parkinson disease.