Findings from this study reveal that prodromal intestinal inflammation promotes the manifestation of PD-related motor impairments across three different mouse models of LRRK2 genetic risk—endogenous mouse LRRK G2019S, transgenic human LRRK2 G2019S, and transgenic human WT LRRK2 overexpression. This evidence concerns the gene LRRK2 and Parkinson disease.