A recent study that investigated the effect of VCN in suppressing the progression of non-alcoholic steatohepatitis (NASH) in mice mentioned that the anti-inflammatory of VCN could be mediated by inhibition of NLRP3 inflammasome activation and hence the NF-κB signaling pathway which results in a reduction in the production of pro-inflammatory cytokines74. Here, NFKB1 is linked to metabolic dysfunction-associated steatohepatitis.