SOD1 and non-small cell lung carcinoma: Similar anticancer mechanisms include the SOD1 inhibitor ATN-224, which specifically inhibits the clearance of hydrogen peroxide within non-small-cell lung cancers (NSCLCs) cells, leading to a P38 MAPK-dependent decrease in MCL1 protein expression (MCL1 expression is positively correlated with cancer cell drug resistance) and cancer cell death120.