The second major finding of this study is that the numbers of baseline CD3+ CD71+, CD3+ CD40L+, CD4+ CD71+, CD4+ CD40L+, CD4+ HLADR+, and CD8+ CD40L+ and the expression of CD3+ CD71+, CD4+ CD71+, and CD4+ HLADR+ are significantly greater in MDD than in controls. Here, TFRC is linked to major depressive disorder.