CXCR2 and colorectal carcinoma: The discovery of the synergistic effects of CCR1 and CXCR2 in myeloid cell recruitment (Fig. 8), as demonstrated by our double-knockout mice model for CCR1 and CXCR2, led us to the intriguing prospect of combining KM5908 and a CXCR2 inhibitor for CRC therapy.