To determine the effect of influenza in the heart, we infected C57BL/6 mice with influenza A/PR/8/34 H1N1 or a PBS control and measured the interferon response genes STAT1, STAT2, Mx1 (MX Dynamin Like GTPase 1), OASL2 (2'-5'-Oligoadenylate Synthetase Like), ISG15 (Interferon stimulated gene-15), and CXCL9 on day 7 after influenza viral treatment. This evidence concerns the gene ISG15 and influenza.