MITF and melanoma: In this aim, we performed an invasion assay using WM1716 and WM1745 cell lines, transfected with siRNA specific for GNPTAB alone or together with siRNA specific for TFEB. Our data demonstrated that inhibition of TFEB expression rescued the invasiveness potential of both melanoma cell lines (Fig. 5b) depleted for GNPTAB. These data indicate that the upregulation of this transcription factor can block invasion, similarly to MITF.