IGF2R and melanoma: Inhibition of IGF2R or GNPTAB had no effect on ductal breast carcinoma cancer cell line MDA-MB-231 invasion, however it drastically inhibited the invasiveness potential of neuroblastoma cell lines SK-N-SH and SK-N-AS, probably since their share the same developmental origin as melanoma, namely neural crest (Fig. 3b and Supplementary Fig. 2a).