We found that ectopically expressed IRE1α sensitized tumor cells to FIN-induced ferroptosis (Fig. 5E), which suggests that pharmacological activation of the RIDD activity of IRE1α may sensitize tumor cells to ferroptosis when combined with other ferroptosis-inducing agents, including FINs, radiation therapy and immunotherapy5,82–86. The gene discussed is ERN1; the disease is neoplasm.