MAP2K7 and cancer: Lai and Friedman used a partial differential equation model that described the dynamics of cancer cells, T cells, proinflammatory cytokines, a BRAF/MEK inhibitor, and a drug that targets the immunoinhibitory receptor PD-1 on T cells to show that combination treatments with the two drugs are positively correlated at low doses, but are antagonistic for some high doses in silico57.