Thus, downregulation of the PTBP1 RBP provides a promising approach for glioblastoma treatment in the future, which might be further developed and optimized, e.g. by parallel overexpression of RBFOX RBPs, as reintroducing RBFOX1 in GBM cell lines was shown to inhibit tumorigenesis and its knock-down was demonstrated to compromise neuronal lineage differentiation of premalignant neural stem cells57. This evidence concerns the gene RBFOX1 and glioblastoma.