PTBP1 and glioblastoma: As expected, the NSC model showed splicing patterns that are comparable to GBM and undifferentiated cells residing in the VZ (Fig. 6d–f), further hinting towards GBM cells representing a less differentiated cellular state in terms of their global splicing pattern, which appears to be broadly driven by the PTBP1 and RBFOX RBPs (Figs. 5a and 6g).