Interestingly, there are multiple splicing events previously reported to be oncogenic among the cassette exons that are differentially spliced-in in normal versus malignant brain tissue and contain binding sites for the PTBP1 RBP, the RBFOX RBPs or both (Fig. 5c and Supplementary Data 7), thereby providing connections between the dysregulation of the PTBP1 and RBFOX RBPs in GBM and the downstream effects on malignant cellular behavior. This evidence concerns the gene PTBP1 and glioblastoma.