Applying MAPP to GBM samples from two additional RNA-Seq cohorts31,32 recapitulated both the PTBP1 and RBFOX expression patterns and the CU-repeat and GCAUG k-mer activities (Supplementary Figs. S8, S9), thereby confirming the PTBP1 and RBFOX RBPs as global regulators of the oncogenic splicing program acting in glioblastomas30,33. This evidence concerns the gene PTBP1 and glioblastoma.