CD5L− mice had elevated blood bacteremia 72 h after CLP, in contrast to the very effective control of systemic infection by WT mice [more than 10,000-fold fewer colony-forming unit (CFU) counts in the blood than CD5L− mice] and, correspondingly, CD5L− mice also had significantly higher bacterial counts in lungs, liver and kidneys than WT controls (Fig. 1c). The gene discussed is CD5L; the disease is bacterial infectious disease with sepsis.