NFE2L2 and cancer: Since we previously showed that KO of NRF2 or KEAP1 did not limit the capacity of 4-OI to promote VSVΔ51 infection in cancer cells (Fig. 4), we further investigated whether the inhibition of the antiviral response to the virus by 4-OI was also modulated independently of the NRF2/KEAP1 axis.