Whereas, knock-down of USP15 dramatically inhibited tumor cell proliferation evidenced by CCK8 and colony formation assays, within K1 and 8505 C, which both represent BRAFV600E-mutated thyroid cancer cells [K1 represents PTC cells, 8505 C represents ATC cells] (Fig. 3a, b, Supplementary Fig. 2d−f). Here, USP15 is linked to thyroid cancer.