CACNA2D2 and epilepsy: Although hilar mossy cell loss is a prominent characteristic of many mouse models of epilepsy (Scharfman, 2016), we found that not only was the mossy cell population intact within the dentate hilus of CACNA2D2 KO mice, but there was a small statistically significant increase in mossy cell density in KO mice (Fig. 4A,B).