CHKB and muscular dystrophy: Interestingly expression of the Chka gene in mice modulates the muscular dystrophy phenotype of its ortholog Chkb as (i) in Chkb−/− mice the affected proximal muscles show a decrease in Chka protein level, whereas unaffected distal muscles show an increase Chka level, and (ii) viral-mediated expression of Chka in affected muscle of Chkb−/− mice ameliorated the muscular dystrophy phenotype (17, 18, 19, 20).