•Severe thrombocytopenia [171–174]•DIC, with grossly elevated aPTT, PT, FDPs [164, 170, 172, 174]•Antithrombin iii, PS, PC below normal range in subset of patients, d-dimer elevated in majority of patients.•Low platelet count, longer PT and aPTT, elevated fibrinogen associated with mortality [174]. This evidence concerns the gene SERPINC1 and Thrombocytopenia.