•not associated with coagulopathy [98, 104], and clotting times remain normal in the majority of Lassa fever patients [98, 105–107].•No thromobocytopenia to moderate thrombocytopenia reported [92, 98, 105–107]•Some evidence of higher d-Dimer [98]•Increase in sTHBS, TF, PAI, ADAMTS13 [98]•Fatal Lassa associated with increased PAI-1, sTM, tPA and antithrombin [99]. The gene discussed is SERPINE1; the disease is Lassa fever.