•Mild Thrombocytopenia [58, 59]•Loss of factors II, V, VII, IX, and X, fibrinogen [60, 61]•dysregulation of the plasmin system [60]•Elevated TT and d-Dimer seen in all cases. Fatal yellow fever associated with elevated APTT, loss of PRC, loss of FII, V, VII, IX [62]. The gene discussed is PLG; the disease is viral infectious disease.