•Thrombocytopenia [26]•Tyrosine phosphorylation of CD31 on platelets [16]•Greater platelet function predictive of good outcome [42]•Elevated d-dimer, prolonged clotting time, high tissue factor [42, 43]. D-dimer, TM associated with fatal outcome [39]•tPA, TF, vWF, thrombomodulin increase over disease course in fatal cases [15, 38]•Elevated NO [26]•Monocytes/macrophages secrete tissue factor [44], tissue factor blockade may be therapeutic [43]. The gene discussed is THBD; the disease is Thrombocytopenia.