•Thrombocytopenia [109, 115, 119] due to megakaryocyte dysfunction [110]•Elevated clotting time [110],•Elevated d-dimer [110], but normal FDP•elevated NO, PGI2 [113], increased plasminogen [120],•prolongation of activated partial thromboplastin time (APTT), low levels of factors VIII, and IX; increased values of factor V, von Willebrand factor, and fibrinogen; decreases in antithrombin III and plasminogen [109]. The gene discussed is PLG; the disease is Thrombocytopenia.