Interestingly, Sfrp1 has been demonstrated to regulate cell proliferation in multiple tumours such as myeloid leukaemia, ovarian cancer and colorectal cancer (Hu et al., 2019; Huang et al., 2014; Liu et al., 2019a; Pehlivan et al., 2017). This evidence concerns the gene SFRP1 and myeloid leukemia.