Of note, case reports have shown that chromosomal duplications of the region where EGR3 is located (8p21.3) are associated with congenital heart disease (i.e., valve and septal defects) (73, 74), while a case-control study has reported an association between an EGR3 locus polymorphism and coronary artery disease (CAD) (75), though with no mention of possible valve defects. Here, EGR3 is linked to coronary artery disorder.