We generated an N-MYC HGSC signature (composed of genes identified as up-regulated in DOX-treated CaOV3 MYCN TET-On cells, above) and validated its positive correlation with MYCN expression based on Nanostring data from formalin fixation and paraffin embedding(FFPE) whole-tumor sections of the same samples (fig. This evidence concerns the gene MYCN and neoplasm.