A key process regulating antitumor immunity in many cancer types involves the sensing of cytoplasmic nucleic acids by the cGAS [cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase]/STING [stimulator of interferon (IFN) genes, encoded by TMEM173] and RIG-I (retinoic acid inducible gene I, encoded by DDX58)–like receptor (RLR) pathways (6). This evidence concerns the gene STING1 and cancer.