In the present study, we discovered that the expressions of downstream inflammatory factors of the TLR4/MyD88/NF-κB signal axis, such like IL-1β, IL-6, Cys-C, SOD1 and TNF-α, as well as Alb, Crea, and BUN levels increased appreciably after the AKI processing in the LPS group. The gene discussed is TLR4; the disease is acute kidney injury.