IL-1β induces both local and systemic inflammation in various autoinflammatory diseases, including allergic asthma, familial mediterranean fever (FMF) and encephalomyelitis (EAE), Tumor necrosis factor-α (TNF-α) is essential for forming a defensive line against pathogenic organisms and has significant effects on the immune system’s normal response by controlling immune cell activation, proliferation, necrosis, and programmed cell death [18,19]. Here, TNF is linked to familial Mediterranean fever.