By targeting on the TLR4 / NF-κB axis to avert LPS-induced AKI response, ACT and ISO inhibited the transcription and translation of inflammatory genes (Rela and Tlr4) and proteins (TLR4, NF-κB, MyD88, IκB-ɑ) expression. The gene discussed is NFKB1; the disease is acute kidney injury.