Yang et al.[98] demonstrated that SHCBP1 (Shc SH2-domain binding protein 1) interacts with EOGT, facilitating O-GlcNAcylation of NOTCH1, thereby promoting pancreatic cancer cell proliferation, migration, invasion, and pancreatic cancer onset and progression. This evidence concerns the gene SHCBP1 and familial pancreatic carcinoma.