Anastasia et al.[91] found that changes in the expression levels of all HS metabolism-involved genes (EXT1, EXT2, NDST1, NDST2, GLCE, 3OST1/HS3ST1, SULF1, SULF2, HPSE) can inhibit the HS-metabolic system in prostate cancer, thereby influencing tumor cell proliferation and migration. The gene discussed is HS3ST1; the disease is Familial prostate cancer.