Among these overlapping genes, SPINK4 showed significant downregulation in tumor samples of GSE32323 and GSE141174 datasets (Figure 1D and 1E), and the findings of the survival study demonstrated that increased SPINK4 expression was linked to good prognosis of CRC patients (Figure 1F), highlighted the possible contribution of SPINK4 in CRC development. The gene discussed is SPINK4; the disease is neoplasm.