CD40LG and gingivitis: The relationship between levels of IgA, IgG, and IgM in saliva and plaque andgingival indices has already been investigated in systemically healthy children (3to 12 years old) with and without gingivitis.21 Analysis of the relationship between immunoglobulin levels and clinicalparameters of gingivitis showed that there was a direct correlation between IgM andgingival index (p < 0.05) in children with gingivitis.