To evaluate the effects of SHP2 in TAM on the migration and invasion abilities of lung adenocarcinoma cells, we coculture transfected THP1 cells with A549 cells and NCI-H1688 cells respectively, and then detect the migration and invasion abilities of A549 and NCI-H1688 cells using cell healing assay and Transwell. This evidence concerns the gene PTPN11 and lung adenocarcinoma.