SLC2A1 and epilepsy: It has been demonstrated that the embryonic lethality of homozygous SLC2A1−/− knockout mice model (Wang et al., 2006), whereas the heterozygous SLC2A1+/− mice model could mimic the features of people with GLUT1 deficiency syndrome, causing brain development delay, epilepsy, cognitive dysfunction, and so on (Benarroch, 2014).