MECP2 and Rett syndrome: In addition, several studies have demonstrated that many Rett syndrome-causing mutations in the methyl-CpG binding domain not only compromise DNA binding capacity of Mecp2 but also reduce its protein stability, implying the relevance of protein stability in Mecp2 dysfunction (Tillotson and Bird, 2020; Chen et al., 2017; Brown et al., 2016).